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FRANCIS A. ELLIS, M.D.

Arch Derm Syphilol. 1944;50(1):27-30.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In an article on vitamin A therapy in cases of Darier's disease Carleton and Steven¹ stated that it occurred to Peck that "since the chief pathologic change is a follicular dyskeratosis, the disease might possibly be due to vitamin A deficiency." They listed follicular hyperkeratosis as one of the diseases associated with vitamin A deficiency which is amenable to vitamin A therapy. Weidman² has expressed the view that "Darier's disease . . . is fundamentally and predominantly keratotic, as witness the original name, dyskeratosis follicularis." Weidman³ wanted to stress the keratotic feature which may be follicular, but he could recall only 1 case in which the sheath of the follicle participated in the dyskeratosis.

These statements induced me to review the literature and to study the biopsy material from 9 cases of typical keratosis follicularis in an attempt to determine whether the primary lesion of Darier's disease is a . . . [Full Text PDF of this Article]

Author Affiliations
BALTIMORE

From the Department of Dermatology, Johns Hopkins University School of Medicine.

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