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EFFECT OF NEOARSPHENAMINE AND MAPHARSEN ON CHOLIC ACID SYNTHESIS AND USE OF DEHYDROCHOLIC ACID TO DIMINISH HEPATOTOXIC ACTION OF MAPHARSEN

J. H. ANNEGERS, M.S.; V. A. DRILL, Ph.D.; J. HABEGGER, B.S.; A. C. IVY, M.D.; A. J. ATKINSON, M.D.

Arch Derm Syphilol. 1945;51(2):112-115.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

This investigation was undertaken to determine (a) whether the intravenous administration of neoarsphenamine and mapharsen affects the synthesis of cholic acid and, if so, (b) whether the oral administration of dehydrocholic acid for three days prior to and after the administration of the arsenicals will diminish the hepatotoxic action of these arsenicals.

This study was stimulated by the clinical report that the administration of sodium dehydrocholate ameliorates arsenical hepatitis.¹ In a previous study² we attempted to ascertain the physiologic rationale of the claim, and found that sodium dehydrocholate did not increase the excretion of the arsenicals in the bile. In fact, sodium dehydrocholate tended to decrease and sodium glycocholate and sodium taurocholate tended to increase the excretion of arsenic in the bile. These tendencies were not statistically significant and could have been due to chance or random sampling. However, an increased excretion of . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Department of Physiology, Northwestern University Medical School.

Footnotes
This study was aided in part by a grant from the Clara L. Abbott Fund.

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