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MARION B. SULZBERGER, M.D.; RUDOLF L. BAER, M.D.; ABRAM KANOF, M.D.; CLARE LOWENBERG, M.S.

Arch Derm Syphilol. 1947;56(1):90-104.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE ORIGINAL work of Peters, Stocken and Thompson¹ demonstrated the great effectiveness of BAL (2,3-dimercaptopropanol) in saving animals systemically poisoned by liquid lewisite and showed the unequivocal benefits which resulted when BAL was applied externally to the skin contaminated by lewisite. Soon after these facts had been established, other research workers began to investigate such immediate practical problems as that of developing stable BAL preparations for topical application to the human skin and eye. It soon became obvious that the vehicle in which BAL was dissolved or suspended played an important role in determining the biologic efficacy and the physical and chemical stability of BAL. For this reason a large number and variety of vehicles had to be prepared and subjected to careful study.

After several groups of investigators had completed a considerable amount of preliminary work on different vehicles and on the technics for their testing, a cooperative . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

Footnotes
The opinions and statements are the private ones of the authors and are not to be construed as those of the Navy Department or the naval service at large.

The work described in this paper was done under a contract, recommended by the Committee on Medical Research, between the Office of Scientific Research and Development and Cornell University Medical College.

Human volunteers for the tests carried out by the authors and described in this paper were made available through the United States Navy at United States Naval Hospital, Brooklyn; United States Naval Midshipmen's School, Columbia University, New York, and United States Naval Disciplinary Barracks, Hart's Island, N. Y.

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