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III. The Therapeutic Activity of Penicillin by Oral Administration

JOHN A. KOLMER, M.D.; Anna M. Rule; Albert J. Paul

Arch Derm Syphilol. 1947;56(3):344-348.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

PENICILLIN by oral administration has not been reported on in the treatment of experimental or human syphilis. However, in view of the results observed in treatment of gonorrhea, pneumonia and other bacterial diseases of human beings by this route of administration, it was thought advisable to ascertain the possible therapeutic activity of penicillin in the treatment of experimental syphilis of rabbits by oral administration.

METHODS AND MATERIALS

In our experiments all rabbits were inoculated intratesticularly with the Nichols-Hough strain of Treponema pallidum. Acute orchitis developed in all, with strongly positive results on dark field examinations about five to six weeks thereafter, when treatment was instituted. Dark field examinations were then made once a day for three days in succession and thereafter once a week over a total period of forty-nine days. At the expiration of this period the popliteal lymph nodes of surviving animals were inoculated into the testicles of . . . [Full Text PDF of this Article]

Author Affiliations
Professor of Medicine, Temple University School of Medicine; Director of the Research Institute of Cutaneous Medicine; PHILADELPHIA

From the Research Institute of Cutaneous Medicine.

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