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THOMAS HODGE McGAVACK, M.D.; PHILIP SCHULMAN, M.D.; RAYMOND SCHUTZER, M.D.; HERBERT ELIAS, M.D.

Arch Derm Syphilol. 1948;57(3 PART I):308-318.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE POWERFUL antihistamine action of "benadryl hydrochloride" N. N. R. (diphenhydramine hydrochloride) has been repeatedly demonstrated in animals¹ and in human beings² with³ and without⁴ allergic diseases. The frequency of the side effects of the drug, when given in adequate amounts by mouth, has led to the following investigation of its topical use for diseases in which cutaneous manifestations of a probably allergic nature are present.

Diphenhydramine hydrochloride has been applied topically in four different ointment bases and in strengths of 2 and 5 per cent, as listed in table 1.⁵

METHODS AND RESULTS

Influence of Diphenhydramine Hydrochloride Ointments on the Histamine Flare and Wheal Reaction in Persons Having no Known Allergic Disease or Other Diseases Associated with Recognizable Disturbances of the Autonomic Nervous System.—

Four tests were performed simultaneously on the skin of each of 63 subjects (28 male and 35 female) on two . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the New York Medical College, Metropolitan Hospital Research Unit, and the Department of Medicine, New York Medical College.

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