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JAMES M. FLOOD, M.D.; JOHN H. STOKES, M.D.

Arch Derm Syphilol. 1948;57(5):810-814.

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IN 1937 two articles appeared in the French literature dealing with the successful treatment of localized scleroderma (morphea) with bismuth compounds. Weissenbach, Lévy-Franckel and Martineau¹ reported improvement in 1 case after the use of sodium bismuth iodide. Sézary² had encouraging results in 2 patients treated with bismuth hydroxide in oil ("muthanol").

After the successful treatment in 2 cases of localized scleroderma, one of us (JHS) suggested the use of bismuth compound in a case presented at the meeting of the Philadelphia Dermatological Society on Dec. 20, 1940.³ Anderson,⁴ following Stokes's suggestion, reported 75 per cent improvement in a girl aged 12, suffering from linear scleroderma of nine years' duration, after twelve injections of bismuth subsalicylate (0.13 Gm. each). Since these preliminary reports, McGuire,⁵ Smith,⁶, Rothman,⁷ Anderson,⁸ Stokes,⁹ Klauder,¹⁰ Counter¹¹ and Anderson¹² have suggested its use or added further . . . [Full Text PDF of this Article]

Author Affiliations
SAYRE, PA.; PHILADELPHIA

From the Section of Dermatology and Syphilology, Guthrie Clinic, Sayre, Pa., and the Graduate School of Medicine, University of Pennsylvania, Philadelphia.

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