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Effect of Quinacrine Hydrochloride on the Incidence of Convulsions

CAPTAIN WILLIAM J. WELCH; ELI BAUMAN, M.D.; CAPTAIN PETER KNOWLTON; ROBERT W. BERLINER, M.D.

Arch Derm Syphilol. 1948;57(5):868-872.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE EFFICACY of quinacrine hydrochloride ("atabrine") in the suppression and treatment of malaria has been demonstrated unequivocally by the experience in both civilian laboratories and the armed forces in recent years. The qualities which make it preferable to quinine as an antimalarial agent are now well recognized,¹ and it seems certain that it will be used widely in the future. For the latter reason, a note of caution is warranted concerning the use of quinacrine hydrochloride in the termination of therapeutic malaria in patients with dementia paralytica.

Toxic psychoses have been previously described as occurring in patients receiving therapeutic doses of quinacrine hydrochloride for clinical malaria, more particularly when medication is administered parenterally.² However, the incidence of this phenomenon is low in otherwise normal persons.

Convulsive seizures are not infrequent in experiments with animals receiving toxic doses of quinacrine hydrochloride. However, their occurrence during the administration of the . . . [Full Text PDF of this Article]

Author Affiliations
Medical Corps, Army of the United States; NEW YORK; Medical Corps, Army of the United States; NEW YORK

From the Department of Medicine, New York University College of Medicine, and the Research Service, Third (New York University) Medical Division, Coldwater Memorial Hospital, New York.

Footnotes
The work described in this paper was done under a contract, recommended by the Committee on Medical Research, between the Office of Scientific Research and Development and New York University.

A portion of this work was presented at the meetings of the Federation of American Societies for Experimental Biology, March 1946 (Welch, W. J.: Knowlton, P.; Bigelow, F. S.; Bauman, E., and Berliner, R. W.: The Incidence of Convulsions in General Paretics Receiving Quinacrine, Federation Proc. 5:213-214 (March) 1946).

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