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An Experimental Study with Report of Injection of Penicillin in Water-in-Oil Emulsion

ALFRED COHN, M.D.; THEODORE ROSENTHAL, M.D.; ISAAK GRUNSTEIN, M.D.

Arch Derm Syphilol. 1948;57(5):900-906.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THIS report deals with various instructive observations recorded in the course of an experimental study of ambulatory treatment of patients with early syphilis with penicillin in water-in-oil emulsion. The commercial production of the original oily vehicle designed for retarding absorption and excretion and used in this investigation¹ has already been replaced by some others, which, however, also employ the same fundamental principles first reported by Freund and Thomson.² Nevertheless, it is hoped that the therapeutic response observed with this type of treatment will promote further research in this direction and also stimulate the investigation of other problems encountered in this study. Our results, therefore, are not intended to present a schedule for routine treatment. What follows is merely a pilot study, which may be used as a guide to a further approach to this problem.

METHOD OF TREATMENT

The use of a single intramuscular injection of sodium penicillin . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Division of Venereal Disease Research (Dr. Cohn and Dr. Grunstein) and the Bureau of Social Hygiene (Dr. Rosenthal), Department of Health, New York.

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