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CHARLES R. REIN, M.D.; THOMAS H. STERNBERG, M.D.; JAMES H. DWINELLE, M.D.; ALBERT J. SHELDON, M.D.

Arch Derm Syphilol. 1948;57(6):942-952.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

SOON after Mahoney, Arnold and Harris¹ demonstrated the efficacy of penicillin therapy in early syphilis, reports appeared in the literature attesting to a similar beneficial role in the treatment of yaws. The earlier publications² (table 1) indicated rapid clinical cure with relatively small doses of penicillin, but only a few patients attained seronegativity with the tests employed. In a preliminary report^2g published by us, the short term results of treatment of 500 patients with early yaws infections in Haiti were discussed. Penicillin was observed to hold definite promise as a therapeutic agent, but the serologic response at the end of three and six month intervals was surprisingly disappointing. The present report deals in detail with evaluation of the serologic results obtained in the entire group treated at the end of twelve months' observations.

METHOD

Five hundred patients with primary and secondary yaws were selected for this study . . . [Full Text PDF of this Article]

Author Affiliations

Footnotes

This is a report of a cooperative research project of the Division of Serology and the Division of Parasitology, Army Medical School, Army Medical Center; Preventive Medical Service, of the Surgeon General, United States Army: Division of Health and Sanitation, Office of Inter-American Affairs, and the Government of the Republic of Haiti.

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