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A. C. IVY, M.D., Ph.D.; CARLOS A. TANTURI, M.D.; R. HERNANDEZ, M.D.; E. BAROSO, M.D.

Arch Derm Syphilol. 1948;58(6):659-674.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

DURING the course of experiments on parenteral nutrition in the dog, H. C. Meng and Smith Freeman¹ observed that the slow intravenous injection of a fat emulsion, stabilized with sorbitol monolaurate (tween 20®), was associated with the development of urticaria. This observation prompted us to undertake a study of the changes which might be related to the development of urticaria, since no other pure substance is known to us which on intravenous injection will consistently cause urticaria. The chemical does not cause urticaria when given orally but does so when introduced intradermally, without previous sensitization of the animal.

In order for one to determine the relation of this experimental urticaria in the dog to that which is produced in man, it will be necessary to review briefly what is known regarding the nature of urticaria in man.

SUMMARY OF KNOWLEDGE OF THE URTICARIAL REACTION

The urticarial reaction consists essentially . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

Research Fellow of the American Gastro Enterological Association.; From the Department of Physiology, Northwestern University and the Department of Clinical Science, University of Illinois.

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