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Use in Treatment of Dermatitis Herpetiformis, Iododerma and Deep Mycotic Infection

THEODORE CORNBLEET, M.D.

Arch Derm Syphilol. 1948;58(6):741-742.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Recently certain synthetic materials have been found that oppose the formation of thyroxin, the active principle of the thyroid gland. This newer group consists of a number of substances, of which thiouracil and propylthiouracil have become the best known. The action of the thyroid gland is intimately connected with the metabolism of iodine since this element is utilized by and in a sense serves to regulate the action of this endocrine structure. It was natural, therefore, to wonder whether the new antithyroid agents would affect dermatologic entities that are influenced by iodides.

Accordingly, 4 patients with dermatitis herpetiformis were treated with propylthiouracil.¹ They were given 100 mg. (2 tablets) three times a day, for ten days for 3 of the subjects and for seven days for 1. At the end of this time none was improved. One of the 3 had more lesions and complained of increased pruritus. The . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Department of Dermatology, University of Illinois College of Medicine, and the Cook County Hospital.

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