
ENHANCING PHOTODYNAMIC EFFECT OF SOLUTIONS OF CRUDE COAL TAR ON THE SKIN
LAWRENCE FRANK, M.D.
Arch Derm Syphilol. 1949;60(4):597-600.
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THE WORK reported in this paper is part of a problem concerned with the development of a method for the effective treatment of psoriasis by photodynamic action.
Lewin1 was the first to recognize that coal tar products are capable of rendering the skin sensitive to sunlight. He found that most of a large group of persons who came repeatedly into contact with certain coal tar products had dermatitis and itching when they were exposed to sunlight. Other investigators in this field included Herxheimer and Nathan,2 Fleishhauer,3 Doniach and Mottram4 and Foerster and Schwartz.5 These early workers established the fact that the action spectrum for tar lies between 3,300 and 5,000 angstrom units and that it is not possible to credit the photosensitizing action of coal tar residues very definitely to any one group of compounds.6 An attempt to employ photodynamic action therapeutically in
. . . [Full Text PDF of this Article]
Author Affiliations
BROOKLYN
From the Long Island College Hospital and the Department of Dermatology and Syphilology, Long Island College of Medicine.
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