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REINFECTION AND RELAPSE AFTER TREATMENT OF EARLY SYPHILIS WITH PENICILLINAnalysis of One Hundred and Thirty-Seven Cases of "Infectious Failure" in a Total Series of 1,105 Cases
ARTHUR G. SCHOCH, M.D.;
LEE J. ALEXANDER, M.D.
Arch Derm Syphilol. 1949;60(5 PART I):690-700.
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WE use the term "infectious failure" (infectious relapse) to describe all cases in which, months or years after treatment with penicillin for early syphilis, patients exhibited dark field positive lesions morphologically typical of primary and/or secondary syphilis. All other types of failures of penicillin therapy were excluded from the study. During the three and one-half years prior to the time of writing, we have collected a sufficient amount of detailed data on 137 cases of infectious failure to enable us to differentiate reinfection and relapse in the majority of instances.
Of the 137 cases subjected to critical, detailed collective and individual analysis, the diagnosis of reinfection was made in 80, leaving 57 in the category of relapse (table 1).
CLINICAL AND LABORATORY FACILITIES FOR COLLECTING DATA
In November 1943, at the beginning of the study of the penicillin therapy of early syphilis, as a specially trained
. . . [Full Text PDF of this Article]
Author Affiliations
DALLAS, TEXAS
From the Department of Dermatology and Syphilology, Southwestern Medical College, and the Dallas Syphilis and Venereal Disease Clinic.
Footnotes
This study was aided by grants from the United States Public Health Service.
Read at the Sixty-Seventh Annual Meeting of the American Dermatological Association, Inc., Murray Bay, Quebec, Canada, June 2, 1947.
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