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ALBERT M. KLIGMAN, Ph.D., M.D.; FRED D. WEIDMAN, M.D.

Arch Derm Syphilol. 1949;60(5 PART I):726-741.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

TORULOSIS is a fatal disease caused by the yeastlike fungus, Cryptococcus neoformans (Torulopsis histolytica, Lodder). The number of reported cases is increasing, and it has become evident that the disease is not as rare as was once thought. More than 120 cases are on record,¹ and the 3 unreported cases that are known to us indicate that there are many more.

The clinical and pathologic features are primarily those of meningoencephalitis.² The disease may simulate other disorders of the central nervous system, particularly tuberculous meningitis and tumor of the brain.

The disease is worldwide. The factors predisposing to infection and the portal of entry are unknown. The histopathology has been excellently described.^2b

Treatment has been eminently unsuccessful, the patients usually dying within four to six months after the appearance of symptoms. The spontaneous remissions which may occur are usually brief. This fact obviously complicates the evaluation . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

From the Department of Dermatology and Syphilology, University of Pennsylvania School of Medicine, Dr. D. M. Pillsbury, Director.

Footnotes
This study was assisted by a grant from the Committee on Therapeutic Research of the Council on Pharmacy and Chemistry of the American Medical Association.

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