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LOTHAR WIRTH, M.D.

Arch Derm Syphilol. 1949;60(6):1206-1207.

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Bismuth sodium triglycollamate (bistrimate®), a new oral bismuth compound for oral administration, has been found effective in systemic bismuth therapy.¹ Only minor side reactions, which were limited to the gastrointestinal tract, were observed-reactions which, after dosage had been temporarily reduced, did not interfere with continued administration of bismuth sodium triglycollamate.² More recently, however, I saw 2 patients exhibit reactions to bismuth sodium triglycollamate which prevented continuation of treatment with this drug, although bismuth subsalicylate given parenterally was tolerated well. I thought it might be worth while to report these cases.

CASE 1.—A 70 year old man with tertiary syphilis of the central nervous system was started on treatment with bismuth sodium triglycollamate in the recommended dosage of 50 mg. three times daily after meals. On the third day of this regimen he exhibited an edematous lower lip, bluish discoloration of its mucosa and continuous salivation. Food . . . [Full Text PDF of this Article]

Author Affiliations
RENSSELAER, N. Y.

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