CUTANEOUS CHANGES IN LUPUS ERYTHEMATOSUSHistopathologic Aspects, with Special Reference to Vascular Changes
WILLIAM G. McCREIGHT, M.D.;
HAMILTON MONTGOMERY, M.D.
Arch Derm Syphilol. 1950;61(1):1-11.
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A REVIEW of lupus erythematosus has been presented in numerous papers.1 The present paper deals with the cutaneous histopathologic aspects of lupus erythematosus, with special reference to the vascular changes within the cutis. It will include a review of the literature directly pertaining to the subject.
REVIEW OF THE LITERATURE
Although the histopathologic changes within the epidermis are secondary to changes within the cutis, they are nevertheless considered to be of great diagnostic significance.2 The changes within the epidermis consist in hyperkeratosis without parakeratosis, keratotic plugging of the hair follicles and glandular orifices and, independent of the foregoing, atrophy and adjacent acanthosis of the rete mucosa and liquefaction degeneration of the basal cell layer.
The histopathologic changes within the cutis are variable; so far as subacute disseminated lupus erythematosus and acute disseminated lupus erythematosus are concerned, there are divergent opinions regarding the interpretation of these changes.
Edema
. . . [Full Text PDF of this Article]
Author Affiliations
Fellow in Dermatology and Syphilology, Mayo Foundation; ROCHESTER, MINN.
From the Section on Dermatology and Syphilology, Mayo Clinic. Abridgment of thesis submitted by Dr. McCreight in August 1948 to the Faculty of the Graduate School of the University of Minnesota in partial fulfilment of the requirements for the degree of Master of Science in Dermatology and Syphilology.
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