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V. The Synergistic or Additive Activity of Penicillin Injected Intramuscularly with Sodium Iodide Administered Orally and Intravenously

JOHN A. KOLMER, M.D.

Arch Derm Syphilol. 1950;61(1):49-55.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

ALTHOUGH the iodides have been employed in the treatment of syphilis since 1821, their mode of action has been obscure. Clinical experience has shown that they have little or no therapeutic effect in the early stages of the disease, this fact being due, it is commonly stated, to the absence of spirocheticidal activity. Thus Tomasczewski¹ in 1910 reported that potassium iodide had no prophylactic or curative activity in the treatment of experimental syphilis of monkeys and rabbits. Nichols² also reported that single intravenous injections of potassium iodide in doses of 0.01 and 0.03 Gm. per kilogram of body weight were ineffective in the treatment of 3 rabbits with acute testicular syphilis, although the intramuscular injection of 1 Gm. per kilogram into a fourth animal resulted in evidences of spirocheticidal activity. At the same time, however, Neisser³ reported that it was possible to prevent the development of . . . [Full Text PDF of this Article]

Author Affiliations
Professor of Medicine, Temple University School of Medicine and School of Dentistry; Director of the Research Institute of Cutaneous Medicine With the Technical Assistance of ANNA M. RULE PHILADELPHIA

From the Research Institute of Cutaneous Medicine.

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