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Report of a Case Treated with Nitrogen Mustard

A. M. BRIXEY, Jr., M.D.; JOHN H. LAMB, M.D.

Arch Derm Syphilol. 1950;61(5):800-812.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

BECAUSE reports in the literature of the use of the nitrogen mustards in cases of cutaneous lymphoblastoma are few, we feel justified in reporting the accompanying case which has been of interest to us because of the dramatic changes brought about, both clinically and histologically, after the administration of methyl-bis (β-chloroethyl) amine.

Many pathologists now consider lymphoblastoma as a generic term in which many single entities are encompassed: lymphosarcoma, lymphatic leukemia, Hodgkin's disease, giant follicular lymphoma (Brill-Symmer disease), reticulum cell sarcoma and mycosis fungoides. That these are all closely related is attested by the frequency of observations of more than one pathologic picture in the same patient¹ and the apparent metamorphosis from one type to another, as from Hodgkin's disease to giant reticulum cell sarcoma or from giant follicular lymphoma to reticulum cell sarcoma.^1b

Many of these diseases have cutaneous manifestations. Leukemia cutis and mycosis fungoides . . . [Full Text PDF of this Article]

Author Affiliations
JOLIET, ILL.; OKLAHOMA CITY

From the Departments of Internal Medicine and Dermatology and Syphilology of the University of Oklahoma School of Medicine and University Hospitals.

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