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DEPOLYMERIZATION OF NUCLEIC ACID IN ACUTE DISSEMINATED LUPUS ERYTHEMATOSUS
BORIS GUEFT, M.D.
Arch Derm Syphilol. 1950;61(6):892-897.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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THE PURPOSE of this presentation is to refer to a previously noted structural alteration that has been observed in lupus erythematosus and to emphasize its significance, which has become evident only after cytochemical analysis.
In 1932 Gross1 reported the presence of "clumps and packets of hematoxylin staining bodies" in the cardiac lesions (fig. 1) of Libman-Sacks disease, later identified with acute lupus erythematosus. He expressed the conclusion that these masses originated in nuclear material and that they were pathognomonic. In 1940, Ginzler and Fox2 found similar masses in necrotic lymph nodes in this disease (fig. 2). They also described basophilic particles in the glomerular loops of the kidney, which observation was confirmed in 1941 by Klemperer, Pollack and Baehr.3
In the past two years my associates and I have observed 4 cases of acute lupus erythematosus in which the same hematoxylin-staining masses were found in
. . . [Full Text PDF of this Article]
Author Affiliations
NEW YORK
Footnotes
Welt Fellow in Pathology, Mount Sinai Hospital.
This paper is the third in a "Symposium on Lupus Erythematosus," held at the Bronx Dermatological Society on Dec. 15, 1950.
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