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CHARLES M. PLOTZ, M.D.; EDWARD L. HOWES, M.D.; J. WALLACE BLUNT, M.D.; KARL MEYER, M.D., Ph.D.; CHARLES RAGAN, M.D.

Arch Derm Syphilol. 1950;61(6):919-921.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

OF FUNDAMENTAL importance is knowledge of the mechanism of action of those adrenal hormones which act beneficially in disseminated lupus erythematosus and other diseases of tissues of mesenchymal origin. Two of the patients described in our clinical discussion¹ showed failure to form granulation tissue while being treated, and 1 had prompt healing when treatment with pituitary adrenocorticotropic hormone (ACTH) was discontinued. In other patients, with rheumatoid arthritis, similar observations have been made.² The question arose of whether ACTH and cortisone might not act by altering the host response to the disease, that is, by halting a connective tissue process which results in the various clinical entities of these diseases.

Accordingly, an experimental evaluation of the effect of various steroids on the connective tissues is going on in our laboratories. Preliminary data³ indicate that cortisone administered to rabbits exerts a profoundly inhibitory effect on . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Departments of Medicine, Surgery and Surgical Pathology, Columbia University College of Physicians and Surgeons, and the Edward Daniels Faulkner Arthritis Clinic of the Presbyterian Hospital.

Footnotes
Postdoctorate Research Fellow, National Institutes of Health, United States Public Health Service.

This paper is the ninth in a "Symposium on Lupus Erythematosus," held at the Bronx Dermatological Society on Dec. 15, 1949.

Supplies of cortisone were obtained from Merck & Co., Inc., through the Committee on Cortisone Research of the National Academy of Sciences, purchased by funds from the United States Public Health Service.

Supported in part by grants from the Masonic Foundation for Medical Research and Human Welfare, the Medical Research and Development Board, Office of the Surgeon General, United States Army, and Office of Naval Research, United States Navy.

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