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ARTHUR B. KERN, M.D.; HERBERT FANGER, M.D.

Arch Derm Syphilol. 1950;62(4):526-532.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

PODOPHYLLIN (resin of podophyllum N.F.), an extract of the dried rhizome and roots of the May apple, or mandrake, has been employed for more than one hundred years as a laxative and more recently as a supposed liver stimulant. In 1942, Kaplan¹ reported successful results in the treatment of condyloma acuminatum with topical application of a 25 per cent suspension of podophyllin in liquid petrolatum.

The rapid involution of the condylomas was assumed by Culp and Kaplan² to be due to spasm of the small vessels induced by the irritant action of the drug, with resultant ischemia and necrosis. However, the histologic studies of treated lesions by Sullivan and King³ suggested a different mode of action. They found that 24 to 48 hours after application of podophyllin the epidermis showed two types of change: superficially there was loss of intercellular bridges with accentuation . . . [Full Text PDF of this Article]

Author Affiliations
PROVIDENCE, R. I.

From the Department of Dermatology, dermatologist in chief, Dr. Francesco Ronchese; Department of Pathology, director, Dr. Herbert Fanger, and Tumor Clinic of the Rhode Island Hospital.

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