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HARRY M. ROBINSON, M.D.; HARRY M. ROBINSON, Jr., M.D.

AMA Arch Derm Syphilol. 1951;63(6):687-701.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE RENEWED interest in syphilotherapy that began with Ehrlich, who at first believed that arsphenamine could eradicate syphilis with one injection, has continued with the hope that some such quick cure could be found. Pollitzer¹ and, in more recent years, Chargin² believed that by giving arsenical treatments daily for a few days or by administering large doses in a slow but continuous drip method one could obtain a cure. However, serious reactions due to intensive arsenical therapy were reported, and in a few instances death occurred.

When Mahoney and co-workers³ reported that injections of penicillin were curative and caused no reactions, it was felt that the ultimate safe cure had been found. It was soon noted that the 600,000 units originally used was not sufficient for cure, and relapses were frequent. Even with the dose increased to 1,200,000 and 2,400,000 units, too many recurrences were noted. It . . . [Full Text PDF of this Article]

Author Affiliations
BALTIMORE

From the Department of Dermatology, University of Maryland School of Medicine.

Footnotes
Read before the Section on Dermatology and Syphilology at the Ninety-Ninth Annual Session of the American Medical Association, San Francisco, June 30, 1950.

Assistance was given us as follows: Sharp and Dohme, Inc., Glenolden, Pa., provided the entire supply of the three varieties of penicillin used and the carinamide. Dr. T. E. Woodward of the Department of Medicine furnished a portion of the chloramphenicol, terramycin and aureomycin used in this study. Parke-Davis & Company, Detroit, supplied chloramphenicol. Lederle Laboratories Division, American Cyanamid Company, Pearl River, N. Y., supplied aureomycin. Dr. F. R. McCrumb Jr., Dr. J. Hightower, Dr. Gerald Martin, Dr. B. Joslin, Dr. R. Bauer and Dr. K. Y. Swisher Jr. also assisted in this study. Credit is also due to the Department of Obstetrics for admitting those patients who were treated with penicillin tablets and penicillin in oil and wax.

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