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A Preliminary Report

GEORGE H. CURTIS, M.D.

AMA Arch Derm Syphilol. 1952;65(2):149-154.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE SEARCH for antibodies in eczematous contact dermatitis has extended principally in three directions: demonstration of the tissue of origin, establishment of a time-route relationship between local and generalization of sensitization, and identification of the antibodies. Sulzberger¹ and Landsteiner² suggested that sensitivity probably originates in the epidermis, although Landsteiner felt that the introduction of allergen on or into the skin was not mandatory. Haxthausen³ concluded that antibodies are produced by the epidermis. By surgical circumvallation of skin islands Landsteiner and Chase⁴ and Rostenberg⁵ indicated that a substance, probably antigen or antibody emanating from the skin, was absorbed via the lymphatics. In guinea pigs Landsteiner and Chase⁶ passively transmitted generalized sensitivity by lymphocytes. Haxthausen⁷ confirmed these results but was unable to demonstrate local passive transmission by lymphocytes in guinea pigs or in man. Sensitizing antibodies demonstrable by passive transfer have been . . . [Full Text PDF of this Article]

Author Affiliations
CLEVELAND

From the Cleveland Clinic and the Frank E. Bunts Educational Institute, Section of Dermatology and Syphilology, Dr. E. W. Netherton, Chief.

Footnotes
Read at the Seventy-First Annual Meeting of the American Dermatological Association, Hot Springs, Va., May 23, 1951.

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