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A Clinicopathologic Study

WILLIAM DIRECTOR, M.D.

AMA Arch Derm Syphilol. 1952;65(2):155-169.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

DIFFERNTIAL diagnosis of the generalized bullous diseases is difficult, especially when individual cases are observed initially or for a short time. As Ormsby and Montgomery¹ state The term pemphigus was formerly applied to every disease of the skin presenting bullae. As knowledge has increased the group has been greatly reduced. The problem is not yet entirely settled, as certain types of multiform erythema and dermatitis herpetiformis are difficult to distinguish from pemphigus. The differentiation of pemphigus vulgaris from the two bullous diseases resembling it most closely, dermatitis herpetiformis and erythema bullosum, is important from at least two viewpoints. First is that of prognosis, a fatal outcome being expected in pemphigus vulgaris. Second is that of drawing conclusions from the responses to therapeutic trials of antibiotics and hormones, such as corticotropin (ACTH) and the adrenal steroids. Obviously, a therapeutic success has entirely different and greater significance when there is . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Department of Dermatology and Syphilology, The Post-Graduate Medical School of New York University-Bellevue Medical Center (Marion B. Sulzberger, M.D., Chairman) and the Service of Dermatology and Syphilology, Bellevue Hospital (Frank C. Combes, M.D., Chief of Service).

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