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Local Effect in the Skin from Topical Application and Local Injection

LEON GOLDMAN, M.D.; LIEUTENANT COLONEL ROBERT G. THOMPSON; CAPTAIN E. RANDOLPH TRICE

AMA Arch Derm Syphilol. 1952;65(2):177-186.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

CORTISONE acetate (cortone®) has been found to have a local effect in various diseases of the eye, especially those of an inflammatory or exudative nature.¹ In ophthalmology, suspensions of cortisone have been used locally as drops and by subconjunctival injection and ointment. In some instances it was necessary to dilute the suspension 1:4 because of local irritation. Special ophthalmic preparations of cortisone with buffered solutions are available. However, topical application does not have any effect on exudation in the vitreous body according to Woods.² After injection into the anterior chamber Woods^1h has reported a heavy flocculent mass disappearing within 24 to 48 hours. After subconjunctival injection remnants can be seen for several weeks. The advantages of local cortisone therapy are obvious. These include the utilization of smaller quantities of medication, avoidance of systemic side-effects, therapy of ambulatory patients, and therapy of aged or debilitated patients. In one . . . [Full Text PDF of this Article]

Author Affiliations
CINCINNATI; MEDICAL CORPS, ARMY OF THE UNITED STATES

From the Department of Dermatology and Syphilology of the University of Cincinnati College of Medicine and the University of Cincinnati, and the Dermatology and Syphilology Section, Walter Reed Army Hospital.

Footnotes
Hypospray® jet injection instruments were furnished by J. M. McKibbin, R. P. Scherer Corporation, Detroit.

Cortisone acetate (cortone®), water-soluble ester of cortisone, and compound F (17-hydroxycorticosterone acetate) were furnished by Dr. J. M. Carlisle, Merck & Company, Inc. Rahway, N. J.

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