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LEON GOLDMAN, M.D.

AMA Arch Derm Syphilol. 1952;65(2):233.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Sulfoxone sodium (diasone®) has been used by Cornbleet¹ since 1944 in the treatment of dermatitis herpetiformis. He has indicated that he has obtained good results. A much less toxic sulfone, also used in the treatment of leprosy, has been under study in the Department of Dermatology at the University of Cincinnati College of Medicine since 1949. This preparation is an acetosulfone (promacetin®) (sodium 4,4'-diaminodiphenylsulfone-2-acetylsulfonamide) for the treatment of sarcoidosis. The toxic reactions seen during this period of study have included only occasional nausea, one probable drug-allergy reaction of pharyngitis, and one drug fever. No serious blood or renal disturbances have been seen, even on prolonged courses. It appears, then, that promacetin® may be used when treatment must be continued for some time.

After Cornbleet's report, promacetin® was used in the treatment of nine patients with dermatitis herpetiformis with an average initial dose each . . . [Full Text PDF of this Article]

Author Affiliations
CINCINNATI

From the Department of Dermatology and Syphilology, University of Cincinnati College of Medicine.

Footnotes
Promacetin® was obtained from Eugene H. Payne, M.D., Parke, Davis & Company, Detroit.

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