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PETER FLESCH, M.D., Ph.D.; MADISON HUNT, Ph.D.

AMA Arch Derm Syphilol. 1952;65(3):261-269.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN A PRELIMINARY report¹ we described the local depilatory effect of the intermediary polymers (dimers) of chloroprene. When painted on the skin of laboratory animals, in all species tested these compounds caused reversible baldness at the site of application. In vitro the dimers inactivated the free sulfhydryl groups of glutathione, human epidermis, and liver homogenates in concentrations which corresponded well with the in vivo depilatory concentrations.²

We attributed the —SH-inhibitory action of the dimers to the unsaturated bonds in the molecule which tie down the —SH groups according to the equation³

On the assumption that the depilatory effect was related to the —SH-inhibitory action of these compounds, we tested a number of unsaturated compounds for their depilatory effectiveness. The substances tested fulfilled the following requirements: 1. All compounds had the —CH=CH— grouping. 2. None of the compounds contained Cl and thus did not give rise to . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA; WILMINGTON, DEL.

From the Department of Dermatology and Syphilology, University of Pennsylvania School of Medicine, and Jackson Laboratory, E. I. DuPont de Nemours & Co.

Footnotes
This work was done in part under a Damon Runyon Senior Clinical Fellowship of the American Cancer Society, Inc.

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