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ERYTHEMA MULTIFORME FOLLOWING DEEP X-RAY THERAPY
JEFF DAVIS, M.D.;
GEORGE T. PACK, M.D.
AMA Arch Derm Syphilol. 1952;66(1):41-48.
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LOCALIZED primary radiation dermatitis resulting from deep x-ray therapy is commonly known, as is the eczematoid dermatitis that sometimes occurs in and about the irradiated site. However, a generalized cutaneous reaction due to radiotherapy, appearing distant to the portal of irradiation, is not well known. Consequently there is a dearth of information on this subject.
In 1903, Holzknecht, the famous Viennese radiologist, reported generalized cutaneous reactions following single large doses of superficial x-rays sufficient to produce moderately severe localized x-ray dermatitis. Since then, sporadic reports have appeared in the dermatological and radiological literature by Epstein,1 Schreiner,2 Kautzky,3 Pardo-Castello,4 Bray,5 Moore,6 Maccagno,7 Castigliano,8 Hopkins,9 and, more recently, Arnold.10
The reaction which may follow deep x-ray therapy consists of a definite symptom complex with characteristic clinical and laboratory features. A generalized rash may appear within 2 to 21 days after
. . . [Full Text PDF of this Article]
Author Affiliations
NEW YORK
From the Department of Surgery and Dermatology, Pack Medical Group.
Footnotes
Instructor in Dermatology, Department of Medicine, New York Hospital and Cornell Medical College (Dr. Davis).
Read before the Section of Dermatology and Syphilology at the 100th Annual Session of the American Medical Association, Atlantic City, N. J., June 15, 1951.
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