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JOSEPH W. GOLDZIEHER, M.D.; IRENE S. ROBERTS, Ph.D.; WILLIAM B. RAWLS, M.D.; MAX A. GOLDZIEHER, M.D.

AMA Arch Derm Syphilol. 1952;66(3):304-315.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

CONSIDERABLE evidence has accumulated showing that steroids applied locally have a profound effect upon the skin and its accessory structures. As early as 1929, Loeb and Haven¹ showed that injection of estrogen into ovariectomized adult guinea pigs accelerated mitosis and proliferation and increased the cell population of the epidermis. In 1937, Kun² demonstrated that the same changes could be induced in infantile or senile rats (i. e., rats with low estrogen production) by the topical administration of estradiol in an ointment. In the skin of the mouse cyclic changes synchronous with the estrous cycle were described by Bullough³ in 1943; maximal activity of the epidermal cells was correlated with the high-estrogen phase of the cycle or could be produced artificially during diestrus by estrogen injections. Recent studies⁴ by means of skin spectrophotometry have demonstrated cutaneous vascular changes in women correlated with fluctuations in estrogen levels; this confirmed the observation of dermovascular reactions . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Research Department, St. Clare's Hospital.

Footnotes
This investigation was supported by a grant from the Division of Research Grants and Fellowships of the National Institutes of Health, United States Public Health Service.

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