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A Clinicopathologic Correlation

WILLIAM DIRECTOR, M.D.

AMA Arch Derm Syphilol. 1952;66(3):343-352.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN PEMPHIGUS vegetans, in contradistinction to pemphigus vulgaris, there is close agreement concerning histologic changes. These are acanthosis and papillomatosis involving predominantly the rete pegs (ridges) and microabscesses within the hyperplastic rete pegs containing large numbers of eosinophiles. I cite a few representative opinions without attempting to review all sources. Montgomery and co-workers¹ state that the histologic changes of pemphigus vegetans are quite distinctive and may occur at any level of the epidermis. Ormsby and Montgomery² are in general agreement, adding that eosinophiles also predominate in the papillae and that there is a resemblance to blastomycosis and bromoderma. Lever³ agrees and mentions that early there is low-level acantholysis as in Darier's disease (keratosis follicularis) but without dyskeratosis; that older lesions show no bullae but only acanthosis and papillomatosis resembling pseudoepitheliomatous hyperplasia, while the intraepidermal abscesses resemble bromoderma and pyogenic granuloma. Civatte,⁴ also in . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Department of Dermatology and Syphilology of the New York University Post-Graduate Medical School (Dr. Marion B. Sulzberger, Chairman) and the Service of Dermatology and Syphilology of Bellevue Hospital (Dr. Frank C. Combes, Chief of Service).

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