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JOHN F. DALY, M.D.

AMA Arch Derm Syphilol. 1952;66(3):393-394.

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The search for safe and effective antipruritic agents has led from time to time to the introduction of many agents of widely varying chemical composition and differing degrees of cutaneous sensitizing properties. The sensitizing potential of most of the surface-active local anesthetic drugs is so well known as to require no comment. In a recent issue of the A. M. A. ARCHIVES OF DERMATOLOGY AND SYPHILOLOGY, Bereston¹ reported an instance of sensitization to crotamiton (N-ethyl-o-crotonotoluide; eurax®). In the same issue of this publication, Lynch and Ockuly² reported a clinical study of the topical use of 1-(β-dimethylaminoethoxy)-3-n-butylisoquinoline monohydrochloride ("quotane") for the relief of itching in a variety of dermatoses. They reported 258 clinical trials in 195 patients in which they encountered only 1 patient who presented an acute reaction resembling contact dermatitis, and by patch testing it was traced to sensitization to the vehicle and not . . . [Full Text PDF of this Article]

Author Affiliations
BURLINGTON, VT.

Footnotes
Associate Professor of Dermatology and Chairman, Division of Dermatology, College of Medicine, University of Vermont.

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