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MATTHEW J. BRUNNER, M.D.; ADELAIDE SMILJANIC, B.S.

AMA Arch Derm Syphilol. 1952;66(6):703-705.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

WITH THE accelerated development of new drugs, cosmetics, dyes, and other materials which may contact the skin, there is an increased need for rapid screening methods for evaluating their sensitizing potentials. Animal tests have little utility, mainly because of species differences in sensitizability. The prophetic patch test procedure suggested by Schwartz and Peck¹ is of value but in some aspects is not entirely adequate for the purpose. In this test, the new material is applied to the skin for 48 hours under an occlusive patch; a group of 200 or more persons is used. The same group is retested in 14 to 21 days; new reactors are deemed to have been sensitized by the first patch test.

Among problems encountered in carrying out this test is, first, the difficulty in distinguishing between allergic and primary irritant patch reactions. With threshold irritants, there may be variation from time to time . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Department of Dermatology, University of Illinois College of Medicine, Francis E. Senear, M.D., Chairman (Dr. Brunner), and the Toni Research Laboratories, Chicago (Miss Smiljanic).

Footnotes
This study was supported in part by a grant from the Toni division of the Gillette Safety Razor Co.

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