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CARROLL S. WRIGHT, M.D.; DONALD N. TSCHAN, M.D.

AMA Arch Derm Syphilol. 1953;67(2):125-128.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE ANTIBIOTIC known as oxytetracycline ("terramycin") is produced from a species of earth mold (Streptomyces rimosus) and as a crystalline amphoteric substance reacting chemically with certain acids or bases to form stable crystalline salts. In contrast to the accidental discovery of penicillin, by Fleming in 1929, the development of oxytetracycline resulted from an organized concentrated search for a therapeutic agent against bacterial, rickettsial, spirochetal, and certain viral and protozoan organisms. The actual program of collecting 100,000 soil samples from a multitude of locations on the various continents of the world has been described by Kane, Finlay, and Sobin.¹ It was after a prolonged screening process that an actinomycete, S. rimosus (so called because of the cracked appearance of the growth on agar medium), yielded a new antibiotic.²

Oxytetracycline was first prepared in pure crystalline form by Regna and Solomons.³ The antibiotic occurs as a bright yellow powder, . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

From the Department of Dermatology, Temple University School of Medicine.

Footnotes
"Terramycin" for this investigation was furnished by Chas. Pfizer & Company, Inc., Brooklyn.

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