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JOSEPH A. ELLIOTT, Jr., M.D.; DON R. MATHIESON, M.D.

AMA Arch Derm Syphilol. 1953;68(2):119-128.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

DISSEMINATED (systemic) lupus erythematosus is a relatively rare disorder. Little is known about its cause, but, because it has features in common with serum sickness, it has been postulated that the disease may be a manifestation of an antigen-antibody reaction.¹ Other workers disagree with this concept.

Heidelberger² has stated that complement acts as an "intensifier" of immune mechanisms. One of us (Mathieson) observed that serum from patients who had disseminated lupus erythematosus produced less hemolysis of sheep erythrocytes than did serum from normal persons. In nine patients who had lupus erythematosus, Sipos and Jáksó³ found normal values for complement in five, slight decrease in value in three, and pronounced decrease in one. In view of these observations, it was considered that an accurate determination of the amount of complement in serum by the quantitative methods developed by Mayer and associates⁴ and by Kent and co-workers . . . [Full Text PDF of this Article]

Author Affiliations
ROCHESTER, MINN.

Footnotes
Fellow in Dermatology and Syphilology, Mayo Foundation (Dr. Elliott Jr.), now practicing in Charlotte, N. C.; Section of Clinical Pathology, Mayo Clinic (Dr. Mathieson).

Abridgment of thesis submitted by Dr. Elliott to the Faculty of the University of Minnesota in partial fulfillment of the requirements for the degree of Master of Science in Dermatology and Syphilology.

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