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AUSTIN H. KUTSCHER, D.D.S.; STANLEY L. LANE, M.D., D.D.S.; EDWARD V. ZEGARELLI, D.D.S., M.S.

AMA Arch Derm Syphilol. 1953;68(2):212-213.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Although a viral etiology has been suggested for recurrent aphthous stomatitis,¹ most investigators have not been able to isolate a virus from recurrent aphthous lesions.² Some investigators, however, have reported that patients with recurrent aphthous stomatitis were benefited by vaccination with smallpox vaccine³ and particularly by the use of intradermal injections of smallpox vaccine.⁴ This study was attempted in an effort to corroborate the latter positive findings.

Each patient presented had a history of recurrent aphthous stomatitis of at least one year's duration (many much longer) and had been observed by us for a prolonged period during the course of placebo and other unsuccessful therapy, some phases of which have already been reported.⁵ In no case was any evidence of accompanying skin lesions noted.

METHODS

Five intradermal injections of smallpox vaccine were administered to each of the 12 patients (four men and eight women, . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the divisions of Research (Hannah and Harry Posner Research Laboratory), Oral Surgery and Oral Diagnosis, of the School of Dental and Oral Surgery of the Faculty of Medicine, Columbia University (Dr. Kutscher, Dr. Lane, and Dr. Zegarelli); Assistant Attending Surgeon, Presbyterian Hospital (Dr. Lane).

Footnotes
Smallpox vaccine for this study was supplied by Lederle Laboratories Division, American Cyanamid Company, Pearl River, N. Y. through the courtesy of Dr. J. M. Ruegsegger.

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