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Clinical Evaluation of New Local Anesthetic

IRWIN I. LUBOWE, M.D.

AMA Arch Derm Syphilol. 1954;69(4):482-485.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

PRURITUS is undoubtedly the most frequent of all the subjective complaints of the patient who seeks dermatological consultation. The etiological factors involved in the production of discomforting pruritus are manifold.

The value of local anesthetics has been ascertained in the alleviation of the discomfort which is experienced in the pruritic dermatoses. I hereby describe my experiences with a new local anesthetic, namely, hexylcaine hydrochloride.

Hexylcaine hydrochloride is the abbreviated generic name for 1-cyclohexylamino-2-propylbenzoate. It is noted that the amino group is not in the paraposition of the benzene ring. The proprietary name for this product is Cyclaine.

Pharmacological and clinical studies were carried out by Beyer and others, Ruben and Anderson, and Orkin and Rovenstine. These investigators established its low toxicity and therapeutic index. Ruben and Anderson, and Orkin and Rovenstine found it an effective agent in spinal anesthesia and nerve block.

Chemical formula of the popular local anesthetics.

Hexylcaine has a molecular weight of 297.85 . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

Footnotes
Hexylcaine (Cyclaine) was supplied by Dr. G. Bayne and Dr. S. Clyde Strickland of Sharp & Dohme, Inc., Medical Research Division, West Point, Pa.

During the past six months, I have been clinically evaluating the antipruritic effect of a 5% hexylcaine preparation in a water-washable base in 56 cases of pruritic dermatosis. The relief of pruritis extends for about four hours. No evidence of sensitization has been observed in these patients. The onset of relief occurs almost instantaneously after the topical application of the hexylcaine cream.

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