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FURTHER STUDIES ON ANTIFUNGAL ACTIVITY OF SOME CINNAMIC ACID DERIVATIVES AND NITROSTYRENES
ARTHUR C. CURTIS, M.D.;
FLORANTE C. BOCOBO, M.D.;
E. RICHARD HARRELL, M.D.;
WALTER D. BLOCK, Ph.D.;
Martin Brooks
AMA Arch Derm Syphilol. 1954;70(6):786-798.
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THE SIMILARITY of the chemical formulae of the two stilbenes, (4,4'-stilbenedicarboxamidine) and diethylstilbesteol (4,4'dihydroxy- ,'-diethylstilbene) was pointed out in previous papers* and their in vitro and in vivo activity against various pathogenic fungi was demonstrated. Stilbamidine has been used clinically in the treatment of North American blastomycosis with favorable results, but at the same time it has exhibited certain objectionable toxic properties, especially trigeminal neuropathy, and, with the present methods of administration and dosage schedules, post-therapeutic recurrences are not too uncommon.3 The in vitro anti-fungal activity of diethylstilbestrol is greater than that of stilbamidine, but its clinical trials in the mycoses are not as extensive as those of stilbamidine. A definite deterrent to its use is its well-known potency as a hormone. These shortcomings led to further studies of the antifungal activity of other members of the stilbene group as well as related compounds, in the
. . . [Full Text PDF of this Article]
Author Affiliations
ANN ARBOR, MICH.
From the Department of Dermatology and Syphilology, University of Michigan Medical School.
Footnotes
Read before the Seventy-Fourth Annual Meeting of the American Dermatological Association, Inc., White Sulphur Springs, W. Va., April 17, 1954.
This study was supported by the Medical Research and Development Board, Office of the Surgeon General, Department of the Army, under Contract No. DA-49-007-Md.
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