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Observations on Patients Treated Over Five Years Ago With 4,008,000 Units of Penicillin

STURE A. M. JOHNSON, M.D.; GERALD T. JANSEN, M.D.; HERMAN H. SHAPIRO, M.D.

AMA Arch Derm Syphilol. 1954;70(6):799-802.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

PENICILLIN therapy of cardiovascular system syphilis has been reported to be efficacious and relatively free from undesirable side-reactions by many observers.^* Unfortunately, most of the reports limit the period of observation to a few months rather than years and make no clear comparison between patients treated with either heavy metals or arsenic and those treated with antibiotics like penicillin. Padget and his group attempted such a study and, after analyzing 1,020 cases treated by various methods and drugs, concluded that individual variation, methods of diagnosis, and systems of case recording made it difficult to appraise therapy. However, they were able to gather sufficient information to state that women had a better prognosis than men, and white patients better than nonwhite. In a similar review of 334 cases, Barnell and Small found that penicillin favorably influenced the prognosis of any type of cardiovascular syphilis and that it was more effective when given before cardiac symptoms had appeared.

In 1951, we . . . [Full Text PDF of this Article]

Author Affiliations
MADISON, WIS.

From the Section of Dermatology and Syphilology and Section of Cardiology of the Department of Medicine of the University of Wisconsin Medical School.

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