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2-Hydroxystilbamidine Observations in Two Cases

THOMAS E. REICHELDERFER, M.D.; EUGENE S. BERESTON, M.D.; MAURICE SULLIVAN, M.D.

AMA Arch Derm. 1955;71(4):462-464.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Since the report of Schoenbach and associates¹ on the use of stilbamidine in the treatment of blastomycosis, the diamidine group of drugs has been investigated for their therapeutic effects against various fungus infections.² Stilbamidine is a relatively unstable and toxic drug and is not acceptable as an experimental drug for the dermatomycoses. Recently^* there was elaborated a more stable, related compound, 2-hydroxystilbamidine, which is less toxic than, and equally as effective as, its predecessor stilbamidine. Favorable results have been reported with its use not only in blastomycosis but also in histoplasmosis, coccidioidomycosis and leishmaniasis. The incidence of kidney, liver, and hemopoietic effects seen after stilbamidine have been absent with 2-hydroxystilbamidine. There has been one doubtful report of fifth nerve neuropathy with 2-hydroxystilbamidine in 125 cases treated with the drug. In this patient there was a question of whether stilbamidine or . . . [Full Text PDF of this Article]

Author Affiliations
Baltimore

From the Division of Dermatology, Department of Medicine, Johns Hopkins University School of Medicine.

Footnotes
2-Hydroxystilbamidine was furnished by The Wm. S. Merrell Company.

This investigation was supported in part by the Medical Research and Development Board, Office of the Surgeon General, Department of the Army, under Contract No. DA-49-007-MD-153, and The Wm. S. Merrell Company, Cincinnati.

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