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CLINICAL EVALUATION OF FIVE-TENTHS PER CENT HYDROCORTISONE OINTMENT
LAWRENCE FRANK, M.D.;
CONRAD STRITZLER, M.D.;
JEROME KAUFMAN, M.D.
AMA Arch Derm. 1955;71(5):637-638.
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Hydrocortisone has now been established as an effective medication for topical use in many dermatologic conditions.* Most investigators have reported on the value of a 1% concentration of hydrocortisone acetate and have stated that concentrations below 1% were of no value. It has recently been shown, however, that the free alcohol of hydrocortisone is more effective topically than the hydrocortisone acetate. Accordingly, an ointment containing a concentration of a 0.5% hydrocortisone free alcohol was clinically evaluated and compared with the same ointment in a 1% concentration. Our results showed that a 0.5% hydrocortisone free alcohol ointment is a useful and effective medication topically.
METHODS AND MATERIALS
Two hundred eighty-two patients were treated with two ointments containing a concentration of 0.5% hydrocortisone free alcohol and 1% hydrocortisone free alcohol.
Wherever possible, contralateral areas were treated with each ointment for comparative evaluation.
. . . [Full Text PDF of this Article]
Author Affiliations
Brooklyn; Queens; Brooklyn
From the Division of Dermatology and Syphilology, Department of Medicine, State University of New York College of Medicine at New York City.
Footnotes
The hydrocortisone ointment used in this study was supplied as Cortril Topical Ointment through the courtesy of Charles Pfizer & Company. Inc.
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