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JAMES H. GRAHAM, M.D.; PAUL LE VAN, M.D.

AMA Arch Derm. 1955;71(5):639-640.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The observed anti-inflammatory effects of parenteral trypsin as reported by numerous authors, including Innerfield and associates,¹ Laufman and Roach,² Fisher and Wilensky,³ Hopen and Campagna,⁴ and others, aroused interest in what effect this enzyme would have upon certain dermatoses characterized by a marked inflammatory component. Many of the previous studies of clinical response to trypsin had been based on both intravenous and intramuscular use of the drug. A review of the toxicity and side-effects of trypsin indicated this substance to have certain hazardous potentials and undesirable side-reactions when administered intravenously. Laufman and Roach² reported side-effects consisting of transitory chills, abdominal cramps, and local irritation and thrombophlebitis at the site of infusion. Innerfield and associates¹ noted transient facial flushing and a sense of warmth and local endophlebitis at the site of infusion. Wright,⁵ in a personal . . . [Full Text PDF of this Article]

Author Affiliations
Los Angeles

From the Division of Dermatology, Department of Medicine, University of California Medical Center, and the Medical Service, Wadsworth General Hospital, Veterans Administration Center.

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