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Effect of Drugs on Galvanic Skin Response LevelA Study in Sympathectomized Human Subjects
DANIEL J. PERRY, M.D.;
GEORGE E. MOUNT, Ph.D.
AMA Arch Derm. 1955;72(2):144-152.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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In 1888 Féré1 described an electrical response of the skin called the psychogalvanic reflex or galvanic skin response (GSR). This is most frequently measured as a change in resistance to a direct current of electricity. Subsequent studies with this phenomenon have resulted in a variety of claims about its site of action and its practical value.
Three theories have been proposed to account for the observed changes. One theory relates the response to muscular activity, another to vasomotor changes, and a third to the sweat glands. At the present time most of the evidence indicates that the GSR is dependent on the sweat glands, more specifically, on some presecretory change in these glands.2 This relationship to sweat glands stimulated our interest in the possibility of adapting the GSR to study the effects of drugs which directly or indirectly affect sweat gland function.
Recently Perry and
. . . [Full Text PDF of this Article]
Author Affiliations
Los Angeles
From the Division of Dermatology, Department of Medicine, University of California School of Medicine at Los Angeles, and the Medical Service, Veterans Administration Center, General Medical and Surgical Hospital (Dr. Perry); and from the Departments of Psychology and Engineering, University of California at Los Angeles (Dr. Mount).
Footnotes
Submitted for publication Jan. 5, 1955.
This study was aided by a grant from G. D. Searle & Co., Chicago.
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