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Evaluation in the Treatment of the Pruritic Dermatoses

IRWIN I. LUBOWE, M.D.

AMA Arch Derm. 1955;72(2):164-170.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Several dermatologists^* have accumulated data describing the therapeutic effectiveness of hydrocortisone compounds when applied topically to the skin in the relief of pruritus associated with atopic dermatoses, neurodermatoses, dermatitis venenata (industrial, household, cosmetic, and plant), pruritus ani and pruritus vulvae.

The hydrocortisone acetate (compound F) and hydrocortisone free alcohol steroid have been utilized in various vehicles.

Sulzberger⁴ described the desirable effects of hydrocortisone acetate in 1%, 2.5%, and 5% in hydrous wool fat (lanolin) petrolatum, and polyethylene glycol (carbowax) bases.

Although different ointment bases were essayed, the specific action of the steriod hydrocortisone, when applied topically to the skin, is conjectural; although its function is known to be morbidostatic, in that it reduces the local epidermal and dermal inflammatory state, permitting the epidermis and subcutaneous tissue to return to normal.

On the basis of animal experimentation, Menkin⁵ suggests that the hydrocortisone acts at the cellular level. . . . [Full Text PDF of this Article]

Author Affiliations
New York

Footnotes
Submitted for publication March 30, 1955

Associate Dermatologist, Metropolitan Hospital, Associate Dermatologist, Flower and Fifth Avenue Hospital.

The hydrocortisone and 9-alpha-fluorohydrocortisone derivatives used in these studies were supplied through the courtesy of Drs. Strickland and Thomas, of Sharp & Dohme, West Point, Pa. The proprietary names of the above preparations are, respectively, "Hydrocortone" and "Alflorone."

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