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Studies on the Percutaneous Absorption of Fludrocortisone
CLARENCE S. LIVINGOOD, M.D.;
JAMES F. HILDEBRAND, M.D.;
JAMES S. KEY, M.D.;
RICHMOND W. SMITH, Jr., M.D.
AMA Arch Derm. 1955;72(4):313-327.
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During the past year, new derivatives of hydrocortisone have been made available. One of these compounds, fludrocortisone (9a-fluorohydrocortisone), was first synthesized by Fried and Sabo1 at the laboratories of the Squibb Institute of Medical Research. It is made by the insertion of the fluorine atom at the 9a position of hydrocortisone acetate. Ointments and lotions containing this drug (hereafter referred to as fludrocortisone) have been evaluated by a number of dermatologists.* Witten and associates4 and Robinson5 are the only investigators to date who have published on this subject. It is the consensus that fludrocortisone  is a potent topical therapeutic agent for the treatment of conditions which respond to hydro-cortisone ointment and lotion. It appears that 0.1%-0.25% fludrocortisone ointment and lotion have at least the same degree of therapeutic efficacy as the 1%-2.5% hydrocortisone preparations; for the local treatment of a
. . . [Full Text PDF of this Article]
Author Affiliations
Detroit
From the Divisions of Dermatology and Endocrinology, Henry Ford Hospital.
Footnotes
Submitted for publication May 27, 1955.
This studywas supported in part by a grant from the Squibb Institute for Medical Research.
Read before the 75th Annual Meeting of the American Dermatological Association, Inc., Belleair, Fla., April 21, 1955.
Chemical studies, except for 17-hydroxycorticosteroids, were done under the direction of Donald G. Remp, Ph.D. The diets were supervised by Miss Harriet Cotton, B.S., Staff dietitian, Henry Ford Hospital.
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