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Report of Two Cases with Hypophyseal Dysfunction

ZYGMUNT LEWITUS, M.D.

AMA Arch Derm. 1956;73(2):158-161.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The Ehlers-Danlos syndrome is a welldefined and distinct clinical entity.¹ As its leading symptoms are cutaneous and its impediment appears at a time when children start to walk, most of the information on it appears in the dermatological and pediatric literature.^* Only a few reports have been published in journals of more general interest ; however, the disease is neither particularly a pediatric nor a dermatological one. It is thought of by most authors as a general developmental disturbance of the mesenchyme. The etiology is probably based on a germ plasma mutation, as emphasized by its hereditary and familial tendency and frequent coexistence with other congenital anomalies.¹⁰

The main constituent features or signs, not all of which need to be present in the same case, are in short¹⁰ as follows:

1. Hyperelasticity of the skin.
   
2. Hyperextensibility of joints.
   
3. Skin friability, especially over bony prominences as
   

Author Affiliations
Petah Tikva, Israel

From the Medical Department A, Beilinson Hospital (Chief: Dr. M. Leffkowitz).

Footnotes
Submitted for publication July 14, 1955.

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