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Pharmacologic Aspects, Uses, and Contraindications in Dermatology

PAUL HIRSCH, M.D.

AMA Arch Derm. 1956;73(4):342-354.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Adrenocortical hormones and corticotropin (ACTH) may yield rapid and beneficial results in specific skin disorders. However, the diversity of hormonal and metabolic effects produced by these agents imposes certain limitations to their use. Consequently, the beneficial results which may accrue must be weighed against the possible ill effects of hormone overdosage. The over-all effects of the hormone must be considered before therapy is undertaken for the purpose of producing a specific action in a specific tissue or organ system.

The purpose of this paper is to review some of the basic pharmacology of the adrenocortical hormones, their new derivatives, and corticotropin, with particular emphasis on potential side-effects and employment in diseases of the skin.

PHARMACOLOGY

The adrenocortical hormones are steroids. Over a period of 20 years, 29 compounds have been isolated, culminating in largescale synthesis for practical use.

In man the adrenal secretory products . . . [Full Text PDF of this Article]

Author Affiliations
Philadelphia

Footnotes
Submitted for publication July 27, 1955.

Read before the Rocky Mountain Dermatological Society, March 26, 1955.

Read before the Sixth Annual Colorado InternResident Clinics, June 2, 1955.

Fludrocortisone (9--fluorohydrocortisone) was supplied through the courtesy of Dr. Elmer Alpert, of Merck Co., Inc.

Work performed while a resident at the University of Colorado School of Medicine. From the Department of Dermatology and Syphilology, University of Colorado School of Medicine (Dr. Osgood S. Philpott, Professor). Dr. Hirsch is now Resident in Dermatology, University Hospital, University of Pennsylvania.

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