This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (2)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Five-Day Treatment

LOUIS CHARGIN, M.D.; WILLIAM LEIFER, M.D.

AMA Arch Derm. 1956;73(5):482-484.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The treatment of syphilis with mercury over the years proved wholly unsatisfactory because such "cures" as it produced were principally symptomatic and rarely, if ever, biologic. With the introduction of the trivalent organic arsenicals the situation changed radically and the much-hoped-for goal of a true biologic cure became a reality. In the experimental animal it was demonstrated that a few doses of the organic arsenicals could completely destroy the treponemes and thus bring about a biologic cure. It was further found that in man even a single adequate dose of the arsenical was capable of curing yaws, a disease closely related to syphilis. Unfortunately, this desideratum was unattainable in human syphilis since large doses, frequently repeated, were necessary. This often resulted in serious toxic reactions and in relapse. This situation soon led to the abandonment of such intensive methods of treatment.

In consequence many prolonged schemes of . . . [Full Text PDF of this Article]

Author Affiliations
New York

Footnotes
Submitted for publication March 2, 1956.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?