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MICHEL PRUNIÉRAS, M.D.; HAMILTON MONTGOMERY, M.D.

AMA Arch Derm. 1956;74(2):177-190.

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This paper pertains to newer histopathologic and histochemical procedures in regard to the cutaneous lesions of systemic lupus erythematosus, especially in regard to the presence of nucleic acids in connective-tissue cells and other cells and the relation of the activity of connective-tissue cells to the extracellular factors of dermal connective tissue, including ground substance. We do not intend to review the characteristic histopathologic features of various types of lupus erythematosus. This has been done recently by Ellis and Bundick^* and also, over a period of years, by one of us (Montgomery) and his associates. Klemperer has summarized the pathologic findings in the internal organs in this disease.

Hargraves and co-workers⁹ have stated that the main characteristic of the lupus erythematosus (L.E.) cell is the loss of chromatin pattern in the fragmented and phagocytized nucleic material; thus, there is a question of disintegration of nucleopro . . . [Full Text PDF of this Article]

Author Affiliations
Rochester, Minn.

Footnotes
Submitted for publication Aug. 12, 1955.

Work represented in this paper was carried out by Dr. Pruniéras as a special volunteer student at the Mayo Clinic and Mayo Foundation, under the supervision of the Section of Dermatology and Syphilology. Opportunity for the performance of special stains was afforded through the cooperation of Dr. A. H. Baggenstoss, Section of Pathologic Anatomy.

Assistant à la Clinique Dermatosyphiligraphique de l'Antiquaille (Prof. J. Gate), Lyon, France; research scholar under grant from the French "Relations Culturelles" and invited by the Mayo Foundation under the Fulbright Act (Dr. Pruniéras); Section of Dermatology and Syphilology, Mayo Clinic and Mayo Foundation (Dr. Montgomery).

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