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A Disease of Changing Concepts

J. GRAHAM SMITH, JR., M.D.

AMA Arch Derm. 1956;74(3):280-285.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Changing concepts have been the hall-mark of necrobiosis lipoidica. It was first described by Oppenheim¹ under the title of dermatitis atrophicans lipoides diabetica, but most of the reported cases have been under the title of necrobiosis lipoidica diabeticorum, as the entity was named by Urbach.² This precedent was followed by Michelson and Laymon³ and Zeisler and Caro in their early reports,⁴ as well as by most other American authors.

A. Necrobiosis Lipoidica and Granuloma Annulare

As early as 1934 it was suggested^* that necrobiosis lipoidica and granuloma annulare might represent variants of the same disease. This concept was presented in detail by Bernstein, Ellis, and Kirby-Smith. However, although the histologic pictures are similar and occasionally clinical differentiation may be difficult, many authorities disagree.

B. Clinical Aspects

In a review of the literature and a study of 8 cases of their own, . . . [Full Text PDF of this Article]

Author Affiliations
Miami, Fla.

From the Division of Dermatology and Syphilology, Department of Medicine, Duke University School of Medicine.

Footnotes
Submitted for publication Nov. 22, 1955.

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