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HERMANN VOLLMER, M.D.

AMA Arch Derm. 1956;74(3):300-301.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Substitution of a fluorine atom at the ninth carbon position¹ enhances materially the electrolytic as well as the antiphlogistic activity of hydrocortisone.² The former property renders fludrocortisone (9-fluorohydrocortisone) unsuitable for systemic therapy,³ the latter promising for topical use.

Studies of Sulzberger⁴ and co-workers and of Robinson,⁵ using the paired comparison method, seem to indicate that fludrocortisone is in many instances superior to hydrocortisone in the topical therapy of various dermatoses, mainly eczema. The majority of Robinson's⁵ patients were treated with fludrocortisone alone without adequate controls. Both of these methods are open to criticism and do not prove beyond doubt the effectiveness of fluorinated hydrocortisone.

Eczema is a capricious disease. Its course depends on a great number of factors besides the topical use of an effective agent. Change of environment such as hospitalization, intercurrent diseases, psychological factors, . . . [Full Text PDF of this Article]

Author Affiliations
New York

Footnotes
Submitted for publication Oct. 10, 1955.

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